Emmet LiveStyle is a Chrome extension paired with a Sublime Text plugin that transforms your CSS workflow. Install both tools and you get no BS live bi-directional CSS editing. To put it another way, either tweak in Chrome DevTools, your Sublime Text CSS file or both, and the changes immediately take effect on your page.
Admittedly LiveStyle isn’t perfect. First you have to be committed to Sublime Text as a text editor (which I’d highly recommend, but it isn’t for everyone). Setup can be sometimes annoying; when you switch to the tool in DevTools you’re often forced to assign CSS files you’re editing manually. Also it’s in beta, so expect occasional stability problems. But for the most part when you start getting in a CSS editing groove it’s pretty awesome.