Designer Nathan Ford’s responsive grid workflow can be boiled down to this quote:
You should design a grid based on your content’s constraints, not design your content based on a grid’s constraints.
It’s rather brilliant when you think about it. It’s also one of the most succinct descriptions of a shift in methodology I’ve been after for a while now, having worked for over a year professionally on responsive web designs. I generally lean heavily on the Skeleton grid system, but something about landing on break points for existing iOS hardware just feels wrong. I’ve got to research Gridset more.